Matt. 12:48; Mark 3:33; Luke 8:21 - Jesus' question about "who are my mother, and sisters and brothers" was also made in reference to Psalm 69:8-9. Jesus the Prophet was answering the psalmist's prophecy that those closest to Him would betray Him at His passion. Jesus is emphasizing the spiritual family's importance over the biological family, and the importance of being faithful to Him. While many were unfaithful to Jesus, Mary remained faithful to Him, even to the point of standing at the foot of the Cross.
Matt. 12:48; Mark 3:33; Luke 8:21 - finally, to argue that Jesus rebuked Mary is to argue that Jesus violated the Torah, here, the 4th commandment. This argument is blasphemous because it essentially says that God committed sin by dishonoring His Mother.
Luke 11:28 - when Jesus says, "Blessed rather are those who hear the word of God and keep it," some Protestants also call this a rebuke of Mary. Again, to the contrary, Jesus is exalting Mary by emphasizing her obedience to God's word as being more critical than her biological role of mother. This affirms Luke 1:48.
Luke 11:28 - also, the Greek word for "rather" is "menounge." Menounge really means "Yes, but in addition," or "Further." Thus, Jesus is saying, yes my mother is blessed indeed, but further blessed are those who hear the word of God and keep it. Jesus is encouraging others to follow Mary's example in order to build up His kingdom.
Luke 11:27-28 - finally, Jesus is the one being complimented, not Mary. Therefore, Jesus is refocusing the attention from Him to others who obey the word of God. If He is refocusing the attention away from Him to others, His comment cannot be a rebuke of Mary His mother.
John 2:4 - this is another example that Protestants use to diminish Mary's significance. Jesus' question to Mary, "what have you to do with me?" does no such thing. To the contrary, Jesus' question illustrates the importance of Mary's role in the kingdom. Jesus' question is in reality an invitation to His mother to intercede on behalf of all believers and begin His ministry, and His Mother understands this. Mary thus immediately intercedes, Jesus obeys her, and performs the miracle which commenced His ministry of redemption.
Luke 8:28 - the demons tell Jesus the same thing, "what have you to do with us." The demons are not rebuking Jesus, for God would not allow it. Instead, the demons are acknowledging the power of Jesus by their question to Him.
John 2:4; 19:26 - when Jesus uses the title "woman" (gnyai), it is a title of dignity and respect. It is the equivalent of Lady or Madam. Jesus honored His Mother as God requires us to do.